Buy procaine hydrochloride cas 51058, a sodium channel blocker and dna methylation inhibitor, from santa cruz. Pubchemprocaine acts mainly by inhibiting sodium influx through voltage gated. The ph was adjusted with sodium hydroxide or hydrochloric acid. Needleless prefilled syringe complies with osha needle. Advice for firefighters penicillin g procaine penicillin g benzathine procaine hydrochloride. The method has characteristics of high yield, simple operation, environment protection, and the like. Msds master report university of california, davis. It should be remembered that the premonitory signs of cortisone overdosage, such as sodium retention and. Procainamide hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1a antiarrhythmic property and analog of procaine. China 51058, procaine hydrochloride manufacturers and. Lidocaine is a synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Procaine hcl novocain was the first synthetic local anesthetic successfully used to produce regional anesthesia.
Procainamide hydrochloride, a group 1a cardiac antiarrhythmic drug, is. Cn1043414a a synthetic method of procaine hydrochloride. Material may be irritating to the mucous membranes and upper respiratory tract. It differs from procaine which is the paminobenzoyl ester of 2diethylaminoethanol. Articaine hydrochloride and epinephrine injection page 1 of 6 section 1. Procaine hydrochloride is a local anesthetic drug of the amino ester group. The pure procaine infusion was firstly described by seifen et al. The method advanced to a routine in many centers for pain treatment, rehabilitation and natural medicine. The present voltammetric method has been successfully used to determine trace paminobenzoic acid in procaine hydrochloride injection and procaine in plasma with a linear relationship of current. Albadr and others published 67 analytical profile of procaine hydrochloride.
Othersprocaine is a local anesthetic of the ester type that has a slow onset and a short duration of action. Find, read and cite all the research you need on researchgate. Linear formula h 2 nc 6 h 4 co 2 ch 2 ch 2 nc 2 h 5 2 hcl. Pdf 67 analytical profile of procaine hydrochloride. Procaine hydrochloride is benzoic acid, 4amino, 2diethylamino ethyl ester, monohydrochloride, the ester of diethylaminoethanol and paraaminobenzoic acid, with the following structural formula.
If the suffix psy, narc or drug precursor, or motbiotox appears, export authorizations are mandatory in france or. The experimental procedure is an adaptation of the synthesis methods for the corresponding unlabelled compounds. Procaine hydrochloride introduced as novocain, the successor to cocaine, has long enjoyed a vogue as a local anesthetic, and its value is well recognized. Jan 01, 1999 ultraviolet absorption spectrum of procaine in a ethanol and in b water.
Extreme high moderate low section 1 chemical product and company identification product name procaine hydrochloride statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. Articaine hydrochloride 4% and epinephrine 100,000 injection articaine hydrochloride 4% and epinephrine 200,000 injection brand name. Procaine hydrochloride51058msds melting point boiling. Smaller 3 m particles columns available for fast uplc. Introduced in 1905 under the trade name novocaine, it became the first and bestknown substitute for cocaine in local anesthesia. Therefore, the veterinarians must be alert to detect less obvious side effects, such as blood dyscrasias, polydipsia, and polyuria. Procaine hydrochloride cas 51058 adipogen life sciences. It is also often combined with lidocaine as a topical preparation for dermal anesthesia lidocaineprilocaine or emla, for treatment of conditions like paresthesia. The invention relates to a synthetic method of procaine hydrochloride. Use of procaine hydrochloride procaine hydrochloride is a local anesthetic drug of the amino ester group. Carbocaine v for nerve block mepivacaine hydrochloride.
Procaine hydrochloride safety data sheet section 2. Procaine hydrochloride ampoule product sheet pdf 22 ko contacts to get additional informations on the product. Procaine hydrochloride ch21cln2o2 cid 5795 structure, chemical names, physical and chemical properties, classification, patents, literature, biological. Application of procaine leads to the depression of neuronal activity. Procaine hydrochloride ep msds exporter lab chemicals. Benzocaine hydrochloride hcl, high purity, 25 grams, 99. For research use only, not for human or veterinary use. Recently its therapeutic value has been realized and many articles have appeared, especially in the foreign literature, attesting its efficiency and emphasizing its clinical potentialities.
Material safety data sheet procaine hydrochloride, 99% acc. Septanest sp articaine hydrochloride 4% and epinephrine 1. Influence of surfactants and surfactantcoated ions on the rate of. Procaine is available as sterile solutions in concentrations of 1% and 2% for injection. Nov 01, 2010 material safety data sheet caffeine msds section 1. Sigmaaldrich offers a number of procaine hydrochloride products. It is a white crystalline, odorless powder that is freely soluble in water, but less soluble in alcohol and has a molecular weight of 272. Synonyms 2ddiethylaminoethyl 4aminobenzoate hydrochloride 4aminobenzoic acid 2diethylaminoethyl ester hydrochloride. Dailymed penicillin penicillin g procaine injection. Procaine is an occasional additive in illicit street drugs, such as cocaine. Procaine is available as sterile solutions in concentrations of 1% and 2% for injection via local infiltration and peripheral nerve block. Sds of procaine hydrochloride, safety data sheets, cas 51058.
May cause eye, skin, and respiratory tract irritation. The stock solution of procaine hydrochloride was prepared in 99. The mixture containing fecl3, fecl22h2o and the surfactant sds or. The procaine infusion the logic following of other parenteral applications since a longtime it is prevalent to finish a neural therapy session with an i. Articaine hydrochloride 4% and epinephrine 200,000 injection brand name. Therapeutic indications of procaine hydrochloride local infiltration anaesthesia and conduction anaesthesia plexic and troncular blocks download documents. Material safety data sheet procaine hydrochloride sc250776 hazard alert code key. Flumazenil competitively inhibits the activity at the benzodiazepine.
Hazardous ingredients present at less than 1% may include methylparaben and sodium metabisulfite. Hold eyelids apart and flush eyes with plenty of water for at least 15 minutes. Procaine hydrochloride cas 51058 sdssafety data sheet. Material safety data sheet pharmaceutical chemistry. Section 1 chemical product and company identification. In its injectable form trade name citanest, it is often used in dentistry. Clinical pharmacology flumazenil, an imidazobenzodiazepine derivative, antagonizes the actions of benzodiazepines on the central nervous system. Procaine hydrochloride, also called novocain, or novocaine, synthetic organic compound used in medicine as a local anesthetic. Novocaine hydrochloride paminobenzoic acid diethylaminoethyl ester hydrochloride formula. Feb 15, 2019 penicillin g procaine injectable suspension alternative method is available in 100ml, 250ml and 500ml multipledose vials. Active ingredient name procainamide hydrochloride chemical formula c h 21 n 3o hcl preparation nonhazardous ingredients include water for injection. Procaine hydrochloride 1% 2% injectable ampoule, injectable. Procaine is an aminobenzoic acid ester, a relatively weak local anesthetic, and has a similar onset of action but short duration compared to other local anesthetic drugs.
Store at controlled room temperature 20 to 25 c 68 to 77 f. Material safety data sheet of procaine hydrochloride abmole. The mobile phase contains an acetonitrile mecn, water, and phosphoric acid. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltagegated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of. The solution may contain hydrochloric acid andor sodium hydroxide for ph adjustment. Benacillin long acting penicillin injection troy laboratories.
Each ml contains 20 mg mepivacaine hydrochloride, 1 mg methylparaben as preservative, and sodium chloride for isotonicity. It contains an ester linkage between the aromatic nucleus and the amino group. It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin. Procainamide hydrochloride reversibly binds to and blocks activated open voltagegated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an. Generally used in a 1 to 10 percent saline solution, procaine hydrochloride is administered by injection for infiltration area flooding as. Penicillin g procaine 300,000 units, procaine hydrochloride.
Mdma manufacturers also use procaine as an additive at ratios ranging from 1. Material safety data sheet phenylpropanolamine hcl msds section 1. Procaine is a local anesthetic drug of the amino ester group. For massspec ms compatible applications the phosphoric acid needs to be replaced with formic acid. A registration number is not available for this substance as the substance. Owing to the ubiquity of the trade name novocain, in some regions, procaine is referred to generically as novocaine. Have eyes examined and tested by medical personnel. Identification of the substancemixture and of the companyundertaking 1.
Procaine hydrochloride is related chemically and pharmacologically to the estertype local anesthetics. Material safety data sheet of procaine hydrochloride. Amitychem corporation manufacture and supply procaine hydrochloride with with high quality, low price and bulk supply. Contents should be used within 90 days after the first dose is removed. Chemical product and company identification product name. The highlydosed infusion with procaine hcl with sodiumbicarbonate as additive was firstly published twenty years ago. Sodium hydroxide andor hydrochloric acid may be use to adjust the ph. First aid measures description of first aid measures. We have been focusing on the research and production of concrete. Procaine hydrochloride can be analyzed by this reverse phase rp hplc method with simple conditions.
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